Discovery of GPCR ligands for probing signal transduction pathways
نویسندگان
چکیده
منابع مشابه
Discovery of GPCR ligands for probing signal transduction pathways
G protein-coupled receptors (GPCRs) are seven integral transmembrane proteins that are the primary targets of almost 30% of approved drugs and continue to represent a major focus of pharmaceutical research. All of GPCR targeted medicines were discovered by classical medicinal chemistry approaches. After the first GPCR crystal structures were determined, the docking screens using these structure...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2014
ISSN: 1663-9812
DOI: 10.3389/fphar.2014.00255